Polynucleotide treatments cause mild, temporary side effects: redness, swelling, and small bumps at the injection site, usually resolving within a few hours to 2 days. Before undergoing Polynucleotide treatment in Leicester, most people have one question in mind: what are the side effects, and how safe is it? This article talks about Polynucleotide treatment side effects in a straightforward and simple manner. This information is taken from the real experiences of patients who come to ND Skin Aesthetics every day for this treatment and our clinical observations.

What Is Polynucleotide?
A polynucleotide is a long chain of linked nucleotides. DNA and RNA are the two forms that underpin all life.
Knowing what a polynucleotide is makes it easier to understand the whole thing. It is basically a bio-regenerative compound made from the DNA of salmon or trout fish, which increases collagen production and helps in tissue repair when injected under the skin. It is also called PDRN and is now a well-known skin booster treatment across the UK.
This treatment is commonly used to:
- Reduce fine lines
- Lighten dark circles under the eyes
- Improve skin texture and radiance
- Reduce hair loss and maintain scalp health
ND Skin Aesthetics Leicester also offers a range of other skin boosters and regenerative therapies, which can be combined as needed.
Do Polynucleotides Work?
Yes, polynucleotides work. This regenerative injectable treatment improves skin quality, hydration, and elasticity from within, not just at the surface.
Do polynucleotides work? The answer to this question is yes, but it becomes clearer when you know how it works. PN is injected into the skin and activates fibroblast cells, which in turn increases collagen and elastin production. It also increases skin hydration levels and speeds up tissue repair. The results depend largely on the correct technique and a clean clinical environment, which is maintained at ND Skin Aesthetics during each session.

Polynucleotide Treatment Side Effects: Common Side Effects
Polynucleotide treatment side effects are mostly mild. The injections use DNA fragments to boost the skin, and whatever shows up at the injection sites tends to settle within one to three days.
Common Side Effects
- Redness and swelling: The needle pricks the skin, so a bit of puffiness is normal. Most of it goes down in a day or two.
- Bruising: You may get a small mark or two around the treated area. It fades by itself, and you can cover it with makeup once the first day or so has passed.
- Small bumps: Little raised spots form where the product went in. They usually flatten out within 12 to 24 hours.
- Tenderness or itching: The area can feel sore, touchy, or a bit itchy.
Less Common and Rare Risks
- Lumps or nodules: Now and then a bump sticks around or the swelling won’t go down. Massage or a check-up with a medical professional may be needed.
- Allergic reaction or infection: Both are rare when a qualified practitioner does the treatment. Polynucleotides usually come from fish DNA, so if you’re allergic to fish, skip this one.
Managing Side Effects
You can deal with most polynucleotide treatment side effects at home.
- Cold compress: Wrap an ice pack in a cloth and hold it on the area to ease swelling and soreness.
- No makeup or heat: For the first 24 to 48 hours, stay away from cosmetics, saunas, and hard workouts.
- Hands off: Don’t rub, press, or massage the area unless your clinician says to.

What Happens Under the Eyes?
Under-eye changes include puffiness, bags, dark circles, and hollowness, caused by fluid shifts, aging, and structural changes beneath the skin.
The skin under the eyes is quite sensitive, so polynucleotide under-eye side effects are a little more noticeable than normal skin, such as temporary swelling or mild puffiness. Polynucleotides under the eyes: immediately after treatment, this swelling can be a bit of a shock to many people at first, but this is completely normal and usually resolves within a day.
What Happens Immediately After Treatment?
After a procedure, you’ll rest in a recovery area while staff monitor your vital signs and treat immediate side effects.
Slight bruising, swelling or redness may occur immediately after the Polynucleotide immediately after injection. Although it may feel a little uncomfortable, it is actually a sign that the treatment has started working. ND Skin Aesthetics practitioners always explain this to the patient after the session, so that no one is unnecessarily worried about this normal reaction.
Serious or Rare Side Effects
Polynucleotide treatment side effects are mostly mild, but some complications can occur over time, such as:
- Allergic reactions
- Risk of infection if the treatment is performed by untrained hands or in an unsterile environment
- Small nodules or granulomas due to incorrect injection technique
This is why it is so important to get your treatment done at a certified and experienced clinic. At ND Skin Aesthetics Leicester, every treatment is carried out with strict hygiene protocols and medical-grade, sealed products, so that this risk is kept to a minimum.

Why Do Side Effects Occur?
Are Polynucleotides Safe or Not? It depends on who is doing the treatment and how it is done. It is usually due to:
- Incorrect injection technique or angle
- Use of low-quality or unapproved products
- Inadequate medical history of the patient
- Treatment by an inexperienced practitioner
Avoiding these issues can greatly reduce the risk of Polynucleotide treatment side effects.
Polynucleotide Aftercare
Following the correct Polynucleotide Aftercare after treatment will reduce side effects quickly and improve results. Some general guidelines include:
- Avoid makeup for 24 hours
- Avoid direct sunlight
- Avoid washing your face with excessively hot water
- Use mild and sensitive-skin-friendly skincare products
- Follow the practitioner’s prescribed follow-up schedule
At ND Skin Aesthetics Leicester, each patient is given individual aftercare guidelines so that they can take proper care of their skin at home.
When to Seek Medical Advice?
You should contact your practitioner without delay if you experience any of the following polynucleotide treatment side effects:
- Persistent swelling or pain that does not go away within a few days
- Fever or pus at the injection site
- Unusual allergic reactions
These symptoms are rare, but it is best to contact your practitioner immediately if they occur.

Who Should Avoid This Treatment?
Polynucleotide Treatment is not suitable for everyone. Those who should avoid it include:
- Pregnant or breastfeeding mothers
- People with skin infections or autoimmune diseases
- People with allergies to fish or seafood
You can book a free consultation at ND Skin Aesthetics Leicester to find out if this treatment is suitable for your specific health situation.
Polynucleotides Results and Before and After Polynucleotides
Polynucleotides Results are not visible all at once, but rather gradually over a number of sessions. Most patients see a clear difference in skin texture, hydration, and radiance after two to three sessions. Before and After Polynucleotides images show that the skin gradually becomes smoother and more youthful, especially in the under-eye area.
Our Doctors’ Experience and Expertise
The team of practitioners at ND Skin Aesthetics Leicester have been working with advanced aesthetic and skin regenerative treatments for a long time. Each of our doctors is fully licensed and has a medical background, regular advanced training in injectable treatments and facial anatomy, and they have real-world experience of successfully treating thousands of patients.
Before creating each treatment plan, a personalized plan is created by carefully examining the patient’s skin type, medical history, and expectations. It is because of this deep experience that ND Skin Aesthetics Leicester is able to control the risk of Polynucleotide treatment side effects and ensure safe and natural results. The real difference is made in the hands of a skilled doctor, not just the product.
Frequently Asked Questions
What You Should Remember?
In short, Polynucleotide Treatment Side Effects are usually mild and temporary in nature. However, its safety and results directly depend on the clinic and the person undergoing the treatment. When done under the supervision of an experienced and licensed doctor, the risks are minimal, and the results are natural and long-lasting.
Do you want a reputable clinic in Leicester with the best team? Then book your free consultation today for ND Skin Aesthetics Leicester. Firstly, our doctors will analyze your skin before composing your treatment plan to guarantee safety.


